Retises 0,5% Nano GelTreatment of skin aging and photoaging. Retinol is the only active ingredient that acts on collagen at 3 levels: repairs (the damage over time has led to the fibers) + stimulation (of new collagen fibers) + protection (to inhibit collagenase). It also regulates melanocyte activity altered by reducing blotchy skin and stimulates proliferation of epidermal keratinocytes (exfoliating). Nicotinamide reduces the transfer of melanosomes to keratinocytes